Home > Research Hubs > Pluripotent stem cells and engineered cells (PSEC) > Publications & Outputs
Search Filters
You are filtering by: Pluripotent stem cells and engineered cells
2023
Epigenetic dynamics during capacitation of naïve human pluripotent stem cells
Agostinho de Sousa J, Wong CW, Dunkel I, Owens T, Voigt P, Hodgson A, Baker D, Schulz EG, Reik W, Smith A, Rostovskaya M, von Meyenn F.Sci Adv. 2023 Sep 29;9(39):eadg1936. doi: 10.1126/sciadv.adg1936. Epub 2023 Sep 29.
Pluripotent stem cells and engineered cells
ISSCR standards for the use of human stem cells in basic research.
Ludwig TE, Andrews PW, Barbaric I, Benvenisty N, Bhattacharyya A, Crook JM, Daheron LM, Draper JS, Healy LE, Huch M, Inamdar MS, Jensen KB, Kurtz A, Lancaster MA, Liberali P, Lutolf MP, Mummery CL, Pera MF, Sato Y, Shimasaki N, and Mosher JTStem Cell Reports, 18:9, p1744-1752, Sep 12, 2023.
Pluripotent stem cells and engineered cells
Lessons learnt, and still to learn, in first in human stem cell trials.
Barker, R.A., Carpenter, M., Jamieson, C.H.M., Murry, C.E., Pellegrini, G., Rao, R.C., & Song, J.Stem Cell Reports, 18:8, p1599-1609, Aug 08 2023. Doi:https://doi.org/10.1016/j.stemcr.2022.11.019
Pluripotent stem cells and engineered cells
Highly efficient platelet generation in lung vasculature reproduced by microfluidics.
Zhao, X., Alibhai, D., Walsh, T.G., Tarassova, N., Englert, M., Birol, S.Z., Li, Y., Williams, C.M., Neal, C.R., Burkard, P., Cross, S.J., Aitken, E.W., Waller, A.K., Ballester Beltrán, J., Gunning, P.W., Hardeman, E.C., Agbani, E.O., Nieswandt, B., Hers, I., Ghevaert, C., & Poole, A.WNat Commun 14, 4026 (2023). https://doi.org/10.1038/s41467-023-39598-9
Blood – Platelets (Megakaryocytes)
, Pluripotent stem cells and engineered cells
The isochromosome 20q abnormality of pluripotent cells interrupts germ layer differentiation.
Vitillo L, Anjum F, Hewitt Z, Stavish D, Laing O, Baker D, Barbaric I, Coffey PStem Cell Reports, Volume 18, Issue 3, 782 - 797. DOI: https://doi.org/10.1016/j.stemcr.2023.01.007
Pluripotent stem cells and engineered cells
Challenges in the clinical advancement of cell therapies for Parkinson’s disease.
Skidmore, S., Barker, R.A.Nat. Biomed. Eng (2023). https://doi.org/10.1038/s41551-022-00987-y
Parkinson’s disease
, Pluripotent stem cells and engineered cells
2022
A reference induced pluripotent stem cell line for large-scale collaborative studies
Pantazis C, Yang A, Lara E, McDonough J, Blauwendraat C, Peng L, Oguro H, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls M, Vitale D, Qi Y, Ramos D, Anderson K, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson M, Aggarwal S, Rosen L, Kirwan P, Pisupati V, Coon S, Scholz S, Coccia E, Sarrafha L, Ahfeldt T, Funes S, Bosco D, Beccari M, Cleveland D, Zanellati M, Basundra R, Deshmukh M, Cohen S, Nevin Z, Matia M, Van Lent J, Timmerman V, Conklin B, Dou D, Holzbaur E, Li E, Rose I, Kampmann M, Priebe T, Öttl M, Dong J, van der Kant R, Erlebach L, Welzer M, Kronenberg-Versteeg D, Abu-Bonsrah D, Parish C, Raman M, Heinrich L, Schüle B, Aristoy C, Verstreken P, Held A, Wainger B, Lyu G, Arenas E, Raulin A, Bu G, Crusius D, Paquet D, Gabriele R, Wray S, Chase K, Zhang K, Marioni J, Skarnes W, Cookson M, Ward M, Merkle F.Cell Stem Cell, 01 Dec 2022, 29(12):1685-1702.e22
DOI: https://doi.org/10.1016/j.stem.2022.11.00410.1016/j.stem.2022.11.004.
Pluripotent stem cells and engineered cells
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells.
Andrews PW, Barbaric I, Benvenisty N, Draper JS, Ludwig T, Merkle FT, Sato Y, Spits C, Stacey GN, Wang H, and Pera MF.Cell Stem Cell. 2022 Dec;29(12):1624-1636. DOI: https://doi.org/10.1016/j.stem.2022.11.006
Pluripotent stem cells and engineered cells
Single nucleotide polymorphism (SNP) arrays and their sensitivity for detection of genetic changes in human pluripotent stem cell cultures.
Steventon-Jones, V., Stavish, D., Halliwell, J. A., Baker, D., & Barbaric, I.Current Protocols Volume 2, Issue 11 e606 doi: https://doi.org/10.1002/cpz1.606
Pluripotent stem cells and engineered cells
Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.
Kuan, W-L, Alfaidi, M, Horne, CB, Vallin, B, Fox, S, Fazal, SV, Williams-Gray, CH, Barker, RA.Brain Pathology. 2022. e13128. https://doi.org/10.1111/bpa.13128
Pluripotent stem cells and engineered cells
Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells
Rouhani, FJ., Zou, X., Danecek, P., Badja, C., Dias Amarante, T., Koh, G., Wu, Q., Memari, Y., Durbin, R., Martincorena, I., Bassett, AR., Gaffney, D., Nik-Zainal, S.Nat Genet (2022) 54, 1406-1416. https://doi.org/10.1038/s41588-022-01147-3
Pluripotent stem cells and engineered cells
The need for a standard for informed consent for collection of human fetal material.
Barker, R.A., Boer, G.J., Cattaneo, E., Charo, R.A., Chuva de Sousa Lopes, S.M., Cong, Y., Fujita,M., Goldman, S., Hermerén, G., Hyun, I., Lisgo, S., Rosser, A.E., Anthony, E., & Lindvall, O.Stem Cell Reports, 2022, Volume 17, Issue 6, 14 June 2022, Pages 1245-1247. https://doi.org/10.1016/j.stemcr.2022.05.013.
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Assessing Cell Competition in Human Pluripotent Stem Cell (hPSC) Cultures.
Price CJ, Barbaric I.Curr Protoc. 2022 May;2(5):e435. doi: 10.1002/cpz1.435.
Pluripotent stem cells and engineered cells
A Mathematical Model of a Valve-Controlled Bioreactor for Platelet Production.
Saville, H., Howard, D., Ghevaert, C., Best, S., Cameron, R., Oliver, J., and Waters, S.Frontiers in Mechanical Engineering. 8. 858931. DOI: https://doi.org/10.3389/fmech.2022.858931
Pluripotent stem cells and engineered cells
Amniogenesis occurs in two independent waves in primates.
Rostovskaya M, Andrews S, Reik W, Rugg-Gunn PJ.Cell Stem Cell. 2022 May;29(5):744-759.e6. DOI: https://doi.org/10.1016/j.stem.2022.03.014
Pluripotent stem cells and engineered cells
Assessment of Automated Flow Cytometry Data Analysis Tools within Cell and Gene Therapy Manufacturing.
Cheung M, Campbell JJ, Thomas RJ, Braybrook J, Petzing J.International Journal of Molecular Sciences. 2022; 23(6):3224. https://doi.org/10.3390/ijms23063224
Pluripotent stem cells and engineered cells
Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells.
Lawrence, M., Shahsavari, A., Bornelöv, S., Moreau, T., Kania, K., Paramor, M., McDonald, R., Baye, J., Perrin, M., Steindel, M., Jimenez-Gomez, P., Penfold, C., Mohorianu, I., and Ghevaert, C.Sci. Adv. 8 (7), DOI: 10.1126/sciadv.abj8618
Blood – Platelets (Megakaryocytes)
, Pluripotent stem cells and engineered cells
Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation.
Merkle, F.T., Ghosh, S., Genovese, G., Handsaker, R.E., Kashin, S., Meyer, D., Karczewski, K. J., O’Dushlaine, C., Pato, C., Pato, M., MacArthur, D.G., McCarroll, S.A., Eggan, K.Cell Stem Cell 1–15 March 3, 2022. https://doi.org/10.1016/j.stem.2022.01.011
Pluripotent stem cells and engineered cells
CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythaemia
Bennett, C., Lawrence, M., Guerrero, J.a., Stritt, S., Waller, A.K, Yan, Y., Mifsud, R.W., Ballester-Beltran, J., Baig, A.A., Mueller, A., Mayer, L., Warland, J., Penkett, C.J., Akbari, P., Moreau, T., Evans, A.L., Mookerjee, S., Hoffman,G.J., Saeb-Parsy, K., Adams, D., Couzens, A.L., Bender, M., Erber, W., Nieswandt, B., Read, R.J., Ghevaert, CBlood 2022; blood.2021013113. doi: https://doi.org/10.1182/blood.2021013113
Blood – Platelets (Megakaryocytes)
, Pluripotent stem cells and engineered cells
Systematic design, generation, and application of synthetic datasets for flow cytometry
Cheung, M., Campbell, J.J., Thomas, R.J., Braybrook, J., Petzing, J.PDA Journal of Pharmaceutical Science and Technology Jan 2022, pdajpst.2021.012659; https://doi.org/10.5731/pdajpst.2021.012659
Pluripotent stem cells and engineered cells
Reduced expression of dopamine D2 receptors on astrocytes in R6/1 HD mice and HD post-mortem tissue
Harris, K.L., Mason, S.L., Vallin, B., Barker, R.A.Neuroscience Letters, 767, 10 January 2022, 136289. https://doi.org/10.1016/j.neulet.2021.136289
Parkinson’s disease
, Pluripotent stem cells and engineered cells
2021
Maintenance of Human Naïve Pluripotent Stem Cells.
Rostovskaya M.In: Rugg-Gunn P. (eds) Human Naïve Pluripotent Stem Cells. Methods in Molecular Biology, vol 2416. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1908-7_6
Pluripotent stem cells and engineered cells
Capacitation of Human Naïve Pluripotent Stem Cells.
Rostovskaya M.In: Rugg-Gunn P. (eds) Human Naïve Pluripotent Stem Cells. Methods in Molecular Biology, vol 2416. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1908-7_9
Pluripotent stem cells and engineered cells
Profiling DNA Methylation in Human Naïve Pluripotent Stem Cells.
von Meyenn F.In: Rugg-Gunn P. (eds) Human Naïve Pluripotent Stem Cells. Methods in Molecular Biology, vol 2416. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1908-7_11
Pluripotent stem cells and engineered cells
Characterizing the genetic stability of human naïve and primed pluripotent stem cells
Baker D., Barbaric I.In: Rugg-Gunn P. (eds) Human Naïve Pluripotent Stem Cells. Methods in Molecular Biology, vol 2416. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1908-7_17
Pluripotent stem cells and engineered cells
Biofunctionalised bacterial cellulose scaffold supports the patterning and expansion of human embryonic stem cell-derived dopaminergic progenitor cells.
Robbins M, Pisupati V, Azzarelli R, Nehme SI, Barker RA, Fruk L, Schierle GSK.Stem Cell Res Ther 12, 574 (2021). https://doi.org/10.1186/s13287-021-02639-5
Parkinson’s disease
, Pluripotent stem cells and engineered cells
The genetic architecture of DNA replication timing in human pluripotent stem cells.
Ding, Q., Edwards, M.M., Wang N., Zhu X., Bracci A.N., Hulke M.L., Hu Y., Tong Y., Hsiao J., Charvet C.J., Ghosh S., Handsaker R.E., Eggan K., Merkle F.T., Gerhardt J., Egli D., Clark A.G., Koren A.Nat Commun 12, 6746 (2021). https://doi.org/10.1038/s41467-021-27115-9
Pluripotent stem cells and engineered cells
Current trends in flow cytometry automated data analysis software.
Cheung, M, Campbell, JJ, Whitby, L, Thomas, RJ, Braybrook, J, Petzing, J.Cytometry. 2021; 99: 1007– 1021. https://doi.org/10.1002/cyto.a.24320
Pluripotent stem cells and engineered cells
Bringing Advanced Therapy Medicinal Products (ATMPs) for Parkinson’s Disease to the Clinic: The Investigator’s Perspective
Barker, R. A., Cutting, E.V., and Daft, D. M.Journal of Parkinson's Disease, vol. 11, no. s2, pp. S129-S134, 2021. DOI: 10.3233/JPD-212563
Parkinson’s disease
, Pluripotent stem cells and engineered cells
The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease.
Qarin S, Howlett SK, Jones JL, Barker RANeuronal Signal. 2021;5(3):NS20200083. Published 2021 Sep 13.
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition
Price CJ, Stavish D, Gokhale PJ, Stevenson BA, Sargeant S, Lacey J, Rodriguez TA, Barbaric IDevelopmental Cell, Online Aug 2021, https://doi.org/10.1016/j.devcel.2021.07.019.
Pluripotent stem cells and engineered cells
Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP.
Lawrence, M., Evans, A., Moreau, T., Bagnati, M., Smart, M., Hassan, E., Hasan, J., Pianella, M., Kerby, J., Ghevaert, C.npj Regen Med 6, 27 (2021). https://doi.org/10.1038/s41536-021-00138-y
Blood – Platelets (Megakaryocytes)
, Pluripotent stem cells and engineered cells
Nanopore sequencing indicates that tandem amplification of chromosome 20q11.21 in human pluripotent stem cells is driven by break induced replication.
Halliwell J, Baker D, Judge K, Quail MA, Oliver K, Betteridge E, Skelton J, Andrews PW, Barbaric I.Stem Cells and Development.Jun 2021.578-586. https://doi.org/10.1089/scd.2021.0013
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.
Zou, X., Koh, G.C.C., Nanda, A.S., Degasperi, A., Urgo, K., Roumeliotis, T.I., Agu, C.A., Badja, C., Momen, S., Young, J., Amarante, T.D., Side, L., Brice, G., Perez-Alonso, V., Rueda, D., Gomez, C., Bushell, W., Harris, R., Choudhary, J.S., Genomics England Research Consortium, Jiricny, J., Skarnes, W.C. & Nik-Zainal, S.Nat Cancer (2021). https://doi.org/10.1038/s43018-021-00200-0
Pluripotent stem cells and engineered cells
Fitness selection in human pluripotent stem cells and interspecies chimeras: Implications for human development and regenerative medicine
Wu, J. and Barbaric, I.Developmental Biology (2021) Volume 476; 209-217. https://doi.org/10.1016/j.ydbio.2021.03.025.
Pluripotent stem cells and engineered cells
Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states.
Chovanec, P., Collier, AJ., Krueger, C., Várnai, C., Semprich, CI., Schoenfelder, S., Corcoran, AE., Rugg-Gunn, PJ.Nat Commun 12, 2098 (2021). https://doi.org/10.1038/s41467-021-22201-4
Pluripotent stem cells and engineered cells
Understanding cell culture dynamics: a tool for defining protocol parameters for improved processes and efficient manufacturing using human embryonic stem cells.
Kusena, J.W.T., Shariatzadeh, M., Thomas, R.J., & Wilson, S.J.Bioengineered, 12:1, 979-996, DOI: 10.1080/21655979.2021.1902696
Pluripotent stem cells and engineered cells
Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives.
Wind, M., Gogolou, A., Manipur, I., Granata, I., Butler, L., Andrews, PW., Barbaric, I., Ning, K., Guarracino, MR., Placzek, M., Tsakiridis, A.Development 2021 148: doi: 10.1242/dev.194415
Pluripotent stem cells and engineered cells
Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.
Jerber, J., Seaton, D.D., Cuomo, A.S.E., Kumasaka, N., Haldane, J., Steer, J., Patel, M., Pearce, D., Andersson, M., Jan Bonder, M., Mountjoy, E., Ghoussaini, M., Lancaster, M.A., HipSci Consortium, Marioni, J.C., Merkle, F.T., Gaffney, D.J., Stegle, O.Nat Genet 53, 304–312 (2021). https://doi.org/10.1038/s41588-021-00801-6
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Chapter 3 – Advances in stem cell biology: induced pluripotent stem cells—novel concepts iPSC-derived megakaryocytes,
Lawrence M., & Ghevaert C.Editor(s): Alexander Birbrair,
In Advances in Stem Cell Biology,
Recent Advances in iPSC-Derived Cell Types,
Academic Press,
Volume 4,
2021,
Pages 49-67,
ISBN 9780128222300,
Blood – Platelets (Megakaryocytes)
, Pluripotent stem cells and engineered cells
The importance of cell culture parameter standardization: an assessment of the robustness of the 2102Ep reference cell line.
Kusena, J.W.T, Shariatzadeh, M., Studd, A.J., James, J.R., Thomas, R.J., & Wilson, S.L.Bioengineered (2021), 12:1, 341-357, DOI: 10.1080/21655979.2020.1870074
Pluripotent stem cells and engineered cells
2020
A blueprint for translational regenerative medicine,
Armstrong JPK, Keane TJ, Roques AC, Stephen Patrick P, Mooney CM, Kuan W-L, Pisupati V, Oreffo ROC, Stuckey D, Watt FM, Forbes SJ, Barker RA, Stevens M.Science Translational Medicine 02 Dec 2020, Vol. 12, Issue 572,
DOI: 10.1126/scitranslmed.aaz2253
Engineered cell environment
, Pluripotent stem cells and engineered cells
, Smart Materials
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence.
Olan I, Parry AJ, Schoenfelder S, Narita M, Ito Y, Chan ASL, Slater G, Bihary D, Bando M, Shirahige K, Kimura H, Samarajiwa SA, Fraser P, Narita M.Nat Commun 11, 6049 (2020).
https://doi.org/10.1038/s41467-020-19878-4
Pluripotent stem cells and engineered cells
, Year
Gene and Cell-Based Therapies for Parkinson’s Disease: Where Are We?
Buttery, P.C., Barker, R.A.Neurotherapeutics (2020) 17, 1539–1562. https://doi.org/10.1007/s13311-020-00940-4
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Animal Models of Parkinson’s Disease: Are They Useful or Not?
Barker, R. A. and Björklund, A.Journal of Parkinson's Disease (2020), 10 (4) pp. 1335-1342, 2020. https://doi.org/10.3233/jpd-202200
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Generation and trapping of a mesoderm biased state of human pluripotency.
Stavish, D., Böiers, C., Price, C., Frith TJ., Halliwell J., Saldana-Guerrero I., Wray J., Brown J., Carr J., James C., Barbaric I, Andrews PW., Enver TNat Commun 11, 4989 (2020).
https://doi.org/10.1038/s41467-020-18727-8
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Acquired genetic changes in human pluripotent stem cells: origins and consequences.
Halliwell, J., Barbaric, I., Andrews, P.WNat Rev Mol Cell Biol (2020).
https://doi.org/10.1038/s41580-020-00292-z
Pluripotent stem cells and engineered cells
GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells.
Vitillo, L., Durance, C., Hewitt, Z., Moore, H.D., Smith, A., Vallier, L.Stem Cell Res Ther 11, 406 (2020).
https://doi.org/10.1186/s13287-020-01915-0
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural Crest.
Firth, T.J.R, Gogolou, A., Hackland, J.O.S., Hewitt, Z.A., Moore, H.D., Barbaric, I., Thapar, N., Burns, A.J., Andrews, P.W., Tsakiridis, A., McCann, C.J.Stem Cell Reports, 15(3) 8 Sep 2020.
https://doi.org/10.1016/j.stemcr.2020.07.024
Pluripotent stem cells and engineered cells
DNA Fiber Assay for the Analysis of DNA Replication Progression in Human Pluripotent Stem Cells.
Halliwell JA, Gravells P, Bryant HE.Current Protocols in Stem Cell Biology. 2020 Sep;54(1):e115. https://doi.org/10.1002/cpsc.115
Pluripotent stem cells and engineered cells
Cohesin-dependent and independent mechanisms support chromosomal contacts between promoters and enhancers.
Thiecke MJ, Wutz G, Muhar M, Tang W, Bevan S, Malysheva V, Stocsits R, Neumann T, Zuber J, Fraser P, Schoenfelder S, Peters JM, Spivakov M.Cell Reports July 2020, 32, 107929,
doi: https://doi.org/10.1016/j.celrep.2020.107929
Pluripotent stem cells and engineered cells
Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells
Halliwell JA, Frith TJR, Laing O, Price CJ, Bower OJ, Stavish D, Gokhale PJ, Hewitt Z, El-Khamisy SF, Barbaric I, Andrews PWStem Cell Reports. 2020 June 9, 14: 1009–1017.
https://doi.org/10.1016/j.stemcr.2020.04.004
Pluripotent stem cells and engineered cells
Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques
Mousavinejad M. , Skidmore S., Barone F. G., Tyers P., Pisupati V., Poptani H., Plagge A., Barker R. A., Murray P., Taylor A., Hill C. J.Mol Imaging Biol 22, 1244–1254 (2020).
doi: 10.1007/s11307-020-01499-4
Parkinson’s disease
, Pluripotent stem cells and engineered cells
A Fluorescent Molecular Imaging Probe with Selectivity for Soluble Tau Aggregated Protein
Zhao YY, Tietz O, Kuan WL, Haji-Dheere AK, Thompson S, Vallin B, Ronchi E, Tóth G, Klenerman D, Aigbirhio FIChemical Science, 2020, 11, 4773-4778.
doi: 10.1039/c9sc05620c
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
Thompson O., von Meyenn F., HewittZ., Alexander J., Wood A., Weightman R., Gregory S., Krueger F., Andrews S., Barbaric I., Gokhale P.J., Moore H.D., Reik W., Milo M., Nik-Zainal S., Yusa K. & Andrews P.W.Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.
Nat Commun 11, 1528 (2020).
https://doi.org/10.1038/s41467-020-15271-3
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease
Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, Breen DP, Cummins G, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams-Gray CH.Brain Behavior and Immunity. 2020; 87:473-488.
doi:10.1016/j.bbi.2020.01.018
Parkinson’s disease
, Pluripotent stem cells and engineered cells
2019
Distributed automated manufacturing of pluripotent stem cell products.
Shariatzadeh M, Chandra A, Wilson SL, McCall MJ, Morizur L, Lesueur L, Chose O, Gepp MM, Schulz A, Neubauer JC, Zimmermann H, Abranches E, Man J, O’Shea O, Stacey G, Hewitt Z, Williams DInt J Adv Manuf Technol 106, 1085–1103 (2020)
doi:10.1007/s00170-019-04516-1
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease.
Kuan WL, Stott K, He X, Wood TC, Yang S, Kwok JCF, Hall K, Zhao Y, Tietz O, Aigbirhio FI, Vernon AC, Barker RAMol Psychiatry 2019 Nov 22.
doi:10.1038/s41380-019-0608-9.
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington’s disease
Kuan WL*, Huefner A*, Mason SL, Mahajan S, Barker RA.Chemical Science, 2020,11, 525-533
doi: 10.1039/c9sc03711j.
Pluripotent stem cells and engineered cells
From protocol to product: ventral midbrain dopaminergic neuron differentiation for the treatment of Parkinson’s disease.
Kusena JWT., Thomas RT., McCall MJ., Wilson SLRegen Med 2019 14:11 https://doi.org/10.2217/rme-2019-0076
Parkinson’s disease
, Pluripotent stem cells and engineered cells
A Professional Standard for Informed Consent for Stem Cell Therapies.
Sugarman J, Barker RA, Charo RA.JAMA. 2019;322(17):1651–1652. doi:10.1001/jama.2019.11290
Pluripotent stem cells and engineered cells
Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease.
Barker, R.A., TRANSEURO consortium.Nat Med (2019) 25, 1045–1053 (2019). https://doi.org/10.1038/s41591-019-0507-2
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Using genome editing to engineer universal platelets
Lawrence M, Mueller A, Ghevaert CEmerg Top Life Sci (2019) 3 (3): 301–311.
doi:10.1042/etls20180153
Blood – Platelets (Megakaryocytes)
, Pluripotent stem cells and engineered cells
Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform.
Stacey GN, Andrews PW, Barbaric I, Boiers C, Chandra A, Cossu G, Csontos L, Frith TJ, Halliwell JA, Hewitt Z, McCall M, Moore HD, Parmar M, Panico MB, Pisupati V, Shichkin VP, Stacey AR, Tedesco FS, Thompson O, Wagey RRegen Med. 2019 Mar;14(3):243-255.
doi: 10.2217/rme-2019-0001. Epub 2019 Apr 2.
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival
Zhang J, Hirst AJ, Duan F, Qiu H, Huang R, Ji Y, Bai L, Zhang F, Robinson D, Jones M, Li L, Wang P, Jiang P, Andrews PW, Barbaric I, Na JStem Cell Reports. 2019 Mar 5;12(3):557-571.
doi:10.1016/j.stemcr.2019.01.013.
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Rapid PCR Assay for Detecting Common Genetic Variants Arising in Human Pluripotent Stem Cell Cultures.
Laing O, Halliwell J, Barbaric ICurr Protoc Stem Cell Biol. 2019 Jun;49(1):e83.
doi:10.1002/cpsc.83. Epub 2019 Mar 1.
Pluripotent stem cells and engineered cells
Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation
Rostovskaya M., Stirparo, G.G., & Smith ADevelopment (2019) 146 (7):dev.172916
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Transcriptional Heterogeneity in Naïve and Primed Human Pluripotent Stem Cells at Single-Cell Resolution
von Meyenn F, Messmer T, Savino A, Santos F, Mohammed H, Tin Long Lun A, Marioni JC, Reik WCell Rep. 2019 Jan 22;26(4):815-824.e4.
doi:10.1016/j.celrep.2018.12.099.
Pluripotent stem cells and engineered cells
2018
Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop.
Stacey G, Andrews P, Asante C, Barbaric I, Barry J, Bisset L, Braybrook J, Buckle R, Chandra A, Coffey P, Crouch S, Driver P, Evans A, Gardner J, Ginty P, Goldring C, Hay DC, Healy L, Hows A, Hutchinson C, Jesson H, Kalber T, Kimber S, Leathers R, Moyle S, Murray T, Neale M, Pan D, Park BK, Rebolledo RE, Rees I, Rivolta MN, Ritchie A, Roos EJ, Saeb-Parsy K, Schröder B, Sebastian S, Thomas A, Thomas RJ, Turner M, Vallier L, Vitillo L, Webster A, Williams D.Regen Med. 2018 Dec;13(8):935-944.
doi: 10.2217/rme-2018-0120. Epub 2018 Nov 29.
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Tackling Ethical Challenges of Premature Delivery of Stem Cell-Based Therapies: ISSCR 2018 Annual Meeting Focus Session Report
Sugarman, J., Barker, RA., Kerridge, I., Lysaght T., Pellegrini, G., Sipp, D., & Tanner, C.Stem Cell Reports (2018), 11 (5), 1021-1025. https://doi.org/10.1016/j.stemcr.2018.10.020
Pluripotent stem cells and engineered cells
Regenerative Therapies for Parkinson’s Disease: An Update
Stoker, T., & Barker, R.BioDrugs (2018), 32 (4), 357-366.
https://doi.org/10.1007/s40259-018-0294-1
Parkinson’s disease
, Pluripotent stem cells and engineered cells
The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards?
Barker, R., Carpenter, M. K., Forbes, S., Goldman, S. A., Jamieson, C., Murry, C. E., Takahashi, J., & Weir G.,Stem cell reports (2018) 10 (5), 1429-1431.
https://doi.org/10.1016/j.stemcr.2018.04.010
Parkinson’s disease
, Pluripotent stem cells and engineered cells
Experimentally integrated dynamic modelling for intuitive optimisation of cell based processes and manufacture
Stacey, A.J., Cheeseman, E.A., Glen, K.E., Moore R.L.L., Thomas, R.J.Biochemical Engineering Journal (2018), 132, 130-138. https://doi.org/10.1016/j.bej.2018.01.012
Cell behaviour, differentiation and manufacturing (UKRMP1)
, Pluripotent stem cells and engineered cells
Returned 73 item(s)