Home > Research Hubs > Engineered cell environment > Publications and Outputs
Search Filters
You are filtering by: Engineered cell environment
2021
Local and systemic responses to SARS-CoV-2 infection in children and adults
Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G. H. Lindeboom, Colin R. Butler, Natsuhiko Kumasaka, Cecilia Dominguez Conde, Lira Mamanova, Liam Bolt, Laura Richardson, Krzysztof Polanski, Elo Madissoon, Josephine L. Barnes, Jessica Allen-Hyttinen, Eliz Kilich, Brendan C. Jones, Angus de Wilton, Anna Wilbrey-Clark, Waradon Sungnak, J. Patrick Pett, Juliane Weller, Elena Prigmore, Henry Yung, Puja Mehta, Aarash Saleh, Anita Saigal, Vivian Chu, Jonathan M. Cohen, Clare Cane, Aikaterini Iordanidou, Soichi Shibuya, Ann-Kathrin Reuschl, Iván T. Herczeg, A. Christine Argento, Richard G. Wunderink, Sean B. Smith, Taylor A. Poor, Catherine A. Gao, Jane E. Dematte, NU SCRIPT Study Investigators* , Gary Reynolds, Muzlifah Haniffa, Georgina S. Bowyer, Matthew Coates, Menna R. Clatworthy, Fernando J. Calero-Nieto, Berthold Göttgens, Christopher O’Callaghan, Neil J. Sebire, Clare Jolly, Paolo de Coppi, Claire M. Smith, Alexander V. Misharin, Sam M. Janes, Sarah A. Teichmann, Marko Z. Nikolić & Kerstin B. MeyerNature, https://doi.org/10.1038/s41586-021-04345-x (2021)
Engineered cell environment
, Lung
Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.
Markides H, Foster NC, McLaren JS, Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I, White LJ, El Haj AJ.Cells. 2021 Jul 14;10(7):1776. doi: 10.3390/cells10071776.
PMID: 34359945
Engineered cell environment
Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel
Foster NC, Allen P, El Haj AJ, Grover LM, Moakes RJA.Adv Healthc Mater. 2021 Jun 23: e2100622. doi: 10.1002/adhm.202100622.
Engineered cell environment
Translational control of stem cell function.
Saba JA, Liakath-Ali K, Green R, Watt FM.Nat Rev Mol Cell Biol. 2021 Jul 16. doi: 10.1038/s41580-021-00386-2. Online ahead of print.
PMID: 34272502 Review.
Engineered cell environment
Sodium hyaluronate supplemented culture medium combined with joint-simulating mechanical loading improves chondrogenic differentiation of human mesenchymal stem cells
Monaco G, El Haj AJ, Alini M, Stoddart MJ.Eur Cell Mater. 2021 Jun 6;41:616-632. doi: 10.22203/eCM.v041a40.
PMID: 34091884
Engineered cell environment
Two-Dimensional and Three-Dimensional Cartilage Model Platforms for Drug Evaluation and High-Throughput Screening Assays
Foster NC, Hall NM, El Haj AJ.Tissue Eng Part B Rev. 2021 May 19. doi: 10.1089/ten.teb.2020.0354.
Engineered cell environment
, Musculoskeletal
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis
Steinberg J, Southam L, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Brooks RA, McCaskie AW, Wilkinson JM, Zeggini E.Ann Rheum Dis. 2021 Apr 26:annrheumdis-2020-219760. doi: 10.1136/annrheumdis-2020-219760. Online ahead of print.
PMID: 33903094
Engineered cell environment
Single-cell multi-omics analysis of the immune response in COVID-19
Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan MD, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolić MZ, Duncan CJA, Smith KGC, Teichmann SA, Clatworthy MR, Marioni JC, Göttgens B, Haniffa M.Nat Med. 2021 Apr 20. doi: 10.1038/s41591-021-01329-2. Online ahead of print.PMID: 33879890
Engineered cell environment
Regenerative medicine meets mathematical modelling: developing symbiotic relationships
Waters S L , Schumacher L J, El Haj APMID: 33846347, PMCID: PMC8042047, DOI: 10.1038/s41536-021-00134-2 Free PMC article
Engineered cell environment
High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need
Hughes R E, Elliot R J R, Dawson J C, Carragher N O.PMID: 33740435 DOI: 10.1016/j.chembiol.2021.02.015
Engineered cell environment
2020
A blueprint for translational regenerative medicine,
Armstrong JPK, Keane TJ, Roques AC, Stephen Patrick P, Mooney CM, Kuan W-L, Pisupati V, Oreffo ROC, Stuckey D, Watt FM, Forbes SJ, Barker RA, Stevens M.Science Translational Medicine 02 Dec 2020, Vol. 12, Issue 572,
DOI: 10.1126/scitranslmed.aaz2253
Engineered cell environment
, Pluripotent stem cells and engineered cells
, Smart Materials
Epithelial Plasticity during Liver Injury and Regeneration
Gadd V L, Aleksieva N, Forbes S JCell Stem Cell 2020 Oct 1;27(4):557-573.
doi: 10.1016/j.stem.2020.08.016.
Engineered cell environment
, Liver
Cell Therapy for Advanced Liver Diseases: Repair or Rebuild
Dwyer B J, Macmillan M T, Brennan P N, Forbes S JJ Hepatol. 2020 Sep 22;S0168-8278(20)33626-6.
doi: 10.1016/j.jhep.2020.09.014.
Engineered cell environment
, Liver
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair
Okuchi Y, Reeves J, Ng S S, Doro D H, Junyent S, Liu K J, El Haj A J & Habib S JNat Mater. 2020 Sep 21.
doi: 10.1038/s41563-020-0786-5.
Engineered cell environment
, Musculoskeletal
Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds
Hamilton N J I, Lee D D H, Gowers K H C, Butler C R, Maughan E F, Jevans B, Orr J C, McCann C J, Burns A J, MacNeil S, Birchall M A, O'Callaghan C, Hynds R E and Janes S M.European Respiratory Journal
DOI: 10.1183/13993003.01200-2019
Engineered cell environment
, Lung
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues,
Ziegler C G K, Allon S J, Nyquist S K ... Shalek A K, Ordovas-Montanes J, HCA Lung Biological NetworkCell (2020)
doi: https://doi.org/10.1016/j.cell.2020.04.035.
Engineered cell environment
, Lung
Controlling Electrospun Polymer Morphology for Tissue Engineering Demonstrated Using hepG2 Cell Line
Bate T S R, Forbes S J, Callanan A.J Vis Exp.(159).
doi: 10.3791/61043.
Engineered cell environment
, Liver
High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery
Hughes R E, Elliott R J R, Munro A F, Makda A, O'Neill J R, Hupp T, Carragher N O.SLAS Discov. 2020 Aug;25(7):770-782.
doi: 10.1177/2472555220917115.
Engineered cell environment
Three-Dimensional Surface-Based Analysis of Cartilage MRI Data in Knee Osteoarthritis: Validation and Initial Clinical Application
MacKay JW, Kaggie JD, Treece GM, McDonnell SM, Khan W, Roberts AR, Janiczek RL, Graves MJ, Turmezei TD, McCaskie AW, Gilbert FJ.J Magn Reson Imaging. 2020 Oct;52(4):1139-1151. doi: 10.1002/jmri.27193. Epub 2020 May 24.
Engineered cell environment
Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing
de la Fuente A G, Queiroz R M L, Ghosh T, McMurran C E, Cubillos J F, Bergles D E, . . . Franklin R J M.Molecular & Cellular Proteomics, 19(8), 1281-1302.
doi:10.1074/mcp.ra120.002102
Engineered cell environment
, Multiple sclerosis
TFEB regulates murine liver cell fate during development and regeneration
Pastore N, Huynh T, Herz N J, Calcagni A, Klisch T J, Brunetti L, Kim K H, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor W R, Moore D D, Settembre C, Finegold M J, Forbes S J, Ballabio A.Nat Commun. 11(1):2461.
doi: 10.1038/s41467-020-16300-x.
Engineered cell environment
, Liver
Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System
Meseguer-Ripolles J, Wang Y, Sorteberg A, Sharma A, Ding N, Lucendo-Villarin B, Kramer P, Segeritz C, Hay DJ. Vis. Exp. (159), e61256
doi:10.3791/61256 (2020)
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Liver
Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration.
Rocchi C, Emmerson E.Trends Mol Med. 2020 Jul;26(7):649-669.
doi.org/10.1016/j.molmed.2020.03.009
Engineered cell environment
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock K, Yoshida M, Barnes J & HCA Lung Biological NetworkNat Med 26, 681–687 (2020).
https://doi.org/10.1038/s41591-020-0868-6
Engineered cell environment
, Lung
Cell-intrinsic differences between human airway epithelial cells from children and adults
Maughan E F, Nigro E, Pennycuick A, Gowers K H C, Denais C, Gómez-López S, Lazarus K A, Butler C R, Lee D D H, Orr J C, Teixeira V H, Hartley B E, Hewitt R J, Al Yaghchi C, Sandhu G S, Birchall M A, O'Callaghan C, Smith C M, De Coppi P, Hynds R E, Janes S M.doi: https://doi.org/10.1101/2020.04.20.027144
Engineered cell environment
, Lung
Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells
Orge I, Gadd V, Barouh V, Rossi E, Carvalho R, Smith I, Allahdadi K, Paredes B, Silva D, Damasceno P, Sampaio G, Forbes S, Soares M & Souza B.Stem Cell Research & Therapy (2020) 11:154
https://doi.org/10.1186/s13287-020-01665-z
Engineered cell environment
, Liver
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose
Laurent D, Semple F, Starkey Lewis P J, Rose E, Black H A, Coe J, Forbes S J, Arends M J, Dear J W, Aitman T J.BMC Med Genomics; 13(1):60.
doi: 10.1186/s12920-020-0705-2.
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Liver
Regional differences in human biliary tissues and corresponding in vitro derived organoids
Rimland C A, Tilson S G, Morell C M, Tomaz R A, Lu W Y, Adams S E, Georgakopoulos N, Otaizo-Carrasquero F, Myers T G, Ferdinand J R, Gieseck R L, Sampaziotis F, Tysoe O C, Wesley B, Muraro D, Oniscu G C, Hannan N F, Forbes S J, Saeb-Parsy K, Wynn T A, Vallier L.Hepatology
doi: 10.1002/hep.31252.
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Liver
Specialized cytonemes induce self-organization of stem cells
Junyent S, Garcin C L, Szczerkowski J L A, Trieu T J, Reeves J, Habib S JProc Natl Acad Sci U S A. 2020 Mar 31;117(13):7236-7244
doi: 10.1073/pnas.1920837117
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Musculoskeletal
Alternatively activated macrophages promote resolution of necrosis following acute liver injury
Starkey Lewis P, Campana L, Aleksieva N, Cartwright J A, Mackinnon A, O'Duibhir E, Kendall T, Vermeren M, Thomson A, Gadd V, Dwyer B, Aird R, Man TY, Rossi A G, Forrester L, Park B K, Forbes S J.J Hepatol. 73(2):349-360
doi: 10.1016/j.jhep.2020.02.031
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Liver
2019
Regenerative Medicine: “Are We There Yet?”
El Haj AJTissue Eng Part A. 2019;25(15-16):1067–1071.
doi:10.1089/ten.TEA.2019.0134
Engineered cell environment
, Musculoskeletal
Remyelination and Ageing: Reversing the Ravages of Time
Neumann B, Segel M, Chalut KJ, Franklin RJMult Scler. 2019;25(14):1835–1841.
doi:10.1177/1352458519884006
Engineered cell environment
Safety Profile of Autologous Macrophage Therapy for Liver Cirrhosis
Moroni F, Dwyer BJ, Graham C, Pass C, Bailey L, Ritchie L, Mitchell D, Glover A, Laurie A, Doig S, Hargreaves E, Fraser AR, Turner ML, Campbell JDM, McGowan NWA, Barry J, Moore JK, Hayes PC, Leeming DJ, Nielsen MJ, Musa K, Fallowfield JA, Forbes SJNat Med 25, 1560–1565 (2019)
doi:10.1038/s41591-019-0599-8
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Liver
Niche Stiffness Underlies the Ageing of Central Nervous System Progenitor Cells
Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez GA, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KJ[published correction appears in Nature. 2019 Aug 29;:].
Nature. 2019;573(7772):130–134.
doi:10.1038/s41586-019-1484-9
Engineered cell environment
Serum Free Production of Three-dimensional Human Hepatospheres from Pluripotent Stem Cells
Lucendo-Villarin B, Rashidi H, Alhaque S, Fischer L, Meseguer-Ripolles J, Wang Y, O'Farrelly C, Themis M, Hay DCJ Vis Exp. 2019;(149):10.3791/59965.
Published 2019 Jul 20.
doi:10.3791/59965
Engineered cell environment
, Liver
2018
3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
Rashidi H, Luu NT, Alwahsh SM, Ginai M, Alhaque S, Dong H, Tomaz RA, Vernay B, Vigneswara V, Hallett JM, Chandrashekran A, Dhawan A, Vallier L, Bradley M, Callanan A, Forbes SJ, Newsome PN, Hay DC.Arch Toxicol (2018).
DOI: https://doi.org/10.1007/s00204-018-2280-2
Engineered cell environment
, Engineering and exploiting the stem cell niche (UKRMP1)
, Liver
Human lung development: recent progress and new challenges
Nikolic, MZ, Sun D, Rawlins ELDevelopment 2018 145: dev163485
doi: 10.1242/dev.163485
Published 15 August 2018
Engineered cell environment
, Lung
Returned 37 item(s)