Imperial College London: Dr. Jenny Puetzer · UK Regenerative Medicine Platform

Professor Kevin Shakesheff, University of Nottingham
Director

Prof Molly Stevens, Imperial College London
Director

Molly Stevens is Professor of Biomedical Materials and Regenerative Medicine and the Research Director for Biomedical Material Sciences in the Institute of Biomedical Engineering at Imperial College. She graduated from Bath University and was awarded a PhD from the University of Nottingham in 2001. Molly conducted post-doctoral studies at the Massachusetts Institute of Technology ahead of joining Imperial in 2004.

Molly’s research uses transformative bioengineering approaches to overcome severe limitations in current materials in biosensing and regenerative medicine. A key focus is on understanding and engineering the biomaterial interface using innovative designs and state of the art materials characterisation methods and using highly multidisciplinary approaches from bioengineers, material scientists, chemists, surgeons and biologists.

Dr. Jenny Puetzer recently joined the Stevens group as a post-doctoral research associate developing biomimetic functionalized scaffolds in August 2014.
Previously, Jenny completed her undergraduate at North Carolina State University in Biomedical Engineering. During this time she researched the effect of hydrostatic pressure and growth factor stimulation on the chondrogenesis of human adipose and bone marrow derived stem cells. Jenny then completed her Ph.D. in Biomedical Engineering at Cornell University with a concentration in Mechanical Engineering. Here she engineered anatomical meniscal constructs with native-like organization, mechanical properties, and anisotropy. Jenny is interested in developing orthopaedic tissues using queues from the natural developmental process in an effort to obtain native organization. Currently, Jenny is serving a one year term on the Young Investigator Council for the journal of Tissue Engineering. Within the Stevens group Jenny will continue her passion for orthopaedic research, with a concentration in scaffold development. Within this hub, Jenny will be developing novel synthetic functionalized polymer-based scaffolds for osteochondral repair that attempt to mimic the architecture, mechanical properties and chemical composition of native tissue.
Publications:
Puetzer JL, Petitte JN, Loboa EG. Comparative Review of Growth Factors for Induction of Three-Dimensional In Vitro Chondrogenesis in Human Mesenchymal Stem Cells Isolated from Bone Marrow and Adipose Tissue. Tissue Engineering Part B. 4: 435. 2010.

Puetzer JL, Williams J, Finger AR, Bernacki SH, Loboa EG. The Effects of Cyclic Hydrostatic Pressure on Viability and Chondrogenesis of Human Adipose and Bone Marrow Derived Adult Stem Cells in 3-D Agarose Constructs. Tissue Engineering Part A. 19: 299. 2012.

Puetzer JL, Ballyns JJ, Bonassar LJ. The Effect of the Duration of Mechanical Stimulation and Post-Stimulation Culture on the Structure and Properties of Dynamically Compressed Tissue-Engineered Menisci. Tissue Engineering Part A. 18: 1365. 2012.

Kim GH, Ahn SH, Lee HJ, Puetzer JL, Bonassar L. Fabrication of Cell-laden Three-dimensional Alginate-scaffolds with an Aerosol Cross-linking Process. Journal of Materials Chemistry.22. 18735. 2012.

Puetzer JL, Brown B, Ballyns JJ, Bonassar LJ. The Effect of IGF-I on Anatomically-shaped Tissue Engineered Menisci. Tissue Engineering Part A. 19: 1443. 2013.

Puetzer JL, Bonassar LJ. High Density Type I Collagen Gels for Tissue Engineering of Whole Menisci. Acta Biomaterialia. 9: 7787. 2013.

Bonnevie ED, Puetzer JL, Bonassar LJ. Enhanced Boundary Lubrication properties of Engineered Menisci by Lubricin Localization with Insulin-like Growth Factor I Treatment. Journal of Biomechanics. 47: 2183. 2014.

Puetzer JL, Bonassar LJ. Native-Like Fiber Development and Mechanical Anisotropy in Tissue Engineered Menisci after Long-Term Anchored Culture. Journal of Biomechanics (in preparation).

Puetzer JL, Bonassar LJ. Effects of Physiologic Loading Patterns on Development of Tissue Engineered Menisci. Proceedings of the National Academy of Science (in preparation).